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Article

PALB2 Variants: Protein Domains and Cancer Susceptibility.

Trends in cancer - 1 Mar 2021

Nepomuceno Thales C, Carvalho Marcelo A, Rodrigue Amélie, Simard Jacques, Masson Jean-Yves, Monteiro Alvaro N A

Abstract excerpt

Since its discovery, partner and localizer of breast cancer 2 (BRCA2) (PALB2) has emerged as a major tumor suppressor gene linked to breast cancer (BC), pancreatic cancer (PC), and ovarian cancer (OC) susceptibility. Its protein product plays a pivotal role in the maintenance of genome integrity. Here we discuss the first functional evaluation of a large set of PALB2 missense variants of uncertain significance...

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Share to Fanconi Anemia Complementation Group N Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Loss of Function Mutation

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Identifiers

PMID: 33139182
DOI: 10.1016/j.trecan.2020.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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