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Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.

Cancer - 1 Apr 2014

Fernandes Priscilla H, Saam Jennifer, Peterson Jenny, Hughes Elisha, Kaldate Rajesh, Cummings Shelly, Theisen Aaron, Chen Sonia, Trost Jeffrey, Roa Benjamin B

Abstract excerpt

BACKGROUND: This study sought to determine the prevalence of PALB2 mutations in a cohort referred for diagnostic testing for hereditary breast cancer. METHODS: Sanger sequencing was used to analyze the entire coding region and flanking introns of PALB2 in anonymized DNA samples from 1479 patients. Samples were stratified into a "high-risk" group, 955 samples from individuals predicted to have a high probability...

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Source

Identifiers

PMID: 24415441
DOI: 10.1002/cncr.28504

Genes

PALB2
BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.PMID 24415441Read ↗

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Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.Semantic proximity Read ↗

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