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Article

Mutation analysis of the PALB2 cancer predisposition gene in familial melanoma.

Familial cancer - 1 Jun 2011

Sabbaghian N, Kyle R, Hao A, Hogg D, Tischkowitz M

Abstract excerpt

PALB2 is a breast and pancreas cancer susceptibility gene whose protein is closely associated with BRCA2 and is essential for BRCA2 anchorage to nuclear structures. This functional relationship made PALB2 a candidate gene for susceptibility to BRCA2-related cancers such as melanoma. The purpose o...

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Source

Identifiers

PMID: 21153565
DOI: 10.1007/s10689-010-9405-y

Genes

PALB2
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21153565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of the PALB2 cancer predisposition gene in familial melanoma.PMID 21153565Read ↗

Assessment of PALB2 as a candidate melanoma susceptibility gene.Semantic proximity Read ↗

Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer.Semantic proximity Read ↗

PALB2 mutations in familial breast and pancreatic cancer.Semantic proximity Read ↗

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.Semantic proximity Read ↗

Mutation analysis of PALB2 gene in French breast cancer families.Semantic proximity Read ↗

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Semantic proximity Read ↗

Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer.Semantic proximity Read ↗

PALB2 and the risks for cancer: implications for clinical care.Semantic proximity Read ↗

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer.Semantic proximity Read ↗

Germline mutations in PALB2 in African-American breast cancer casesSemantic proximity Read ↗

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