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Article

Mutation analysis of the PALB2 cancer predisposition gene in familial melanoma.

Familial cancer - 1 Jun 2011

Sabbaghian N, Kyle R, Hao A, Hogg D, Tischkowitz M

Abstract excerpt

PALB2 is a breast and pancreas cancer susceptibility gene whose protein is closely associated with BRCA2 and is essential for BRCA2 anchorage to nuclear structures. This functional relationship made PALB2 a candidate gene for susceptibility to BRCA2-related cancers such as melanoma. The purpose of this study was to screen for the presence of germline mutations in PALB2 in familial melanoma cases. We sequenced the...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21153565
DOI: 10.1007/s10689-010-9405-y

Genes

PALB2
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of the PALB2 cancer predisposition gene in familial melanoma.PMID 21153565Read ↗

Assessment of PALB2 as a candidate melanoma susceptibility gene.Semantic proximity Read ↗

Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer.Semantic proximity Read ↗

PALB2 mutations in familial breast and pancreatic cancer.Semantic proximity Read ↗

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.Semantic proximity Read ↗

Mutation analysis of PALB2 gene in French breast cancer families.Semantic proximity Read ↗

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Semantic proximity Read ↗

Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer.Semantic proximity Read ↗

PALB2 and the risks for cancer: implications for clinical care.Semantic proximity Read ↗

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer.Semantic proximity Read ↗

Germline mutations in PALB2 in African-American breast cancer casesSemantic proximity Read ↗

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