Article
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
Oncogene - 20 Jul 2017
Foo T K, Tischkowitz M, Simhadri S, Boshari T, Zayed N, Burke K A, Berman S H, Blecua P, Riaz N, Huo Y, Ding Y C, Neuhausen S L, Weigelt B, Reis-Filho J S, Foulkes W D, Xia B
Abstract excerpt
The major breast cancer suppressor proteins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which is thought to be critical for tumor suppression. The two BRCA proteins are linked by a third tumor suppressor, PALB2, in the HR pathway. While truncating mutations in these genes are generally pathogenic, interpretation of missense variants remains a challenge. To date,...
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