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Article

Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia.

Blood advances - 14 Jun 2022

Yamato Genki, Kawai Tomoko, Shiba Norio, Ikeda Junji, Hara Yusuke, Ohki Kentaro, Tsujimoto Shin-Ichi, Kaburagi Taeko, Yoshida Kenichi, Shiraishi Yuichi, Miyano Satoru, Kiyokawa Nobutaka, Tomizawa Daisuke, Shimada Akira, Sotomatsu Manabu, Arakawa Hirokazu, Adachi Souichi, Taga Takashi, Horibe Keizo, Ogawa Seishi, Hata Kenichiro, Hayashi Yasuhide

Abstract excerpt

We investigated genome-wide DNA methylation patterns in 64 pediatric patients with acute myeloid leukemia (AML). Based on unsupervised clustering with the 567 most variably methylated cytosine guanine dinucleotide (CpG) sites, patients were categorized into 4 clusters associated with genetic alterations. Clusters 1 and 3 were characterized by the presence of known favorable prognostic factors, such as...

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Identifiers

PMID: 35008106
DOI: 10.1182/bloodadvances.2021005381
PMCID: PMC9198913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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