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Article

Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis

24 Dec 2009

Abstract excerpt

The nuclear poly(A)-binding protein 1 (PABPN1) is a ubiquitously expressed protein that plays a critical role in polyadenylation. Short expansions of the polyalanine tract in the N-terminus of PABPN1 lead to oculopharyngeal muscular dystrophy (OPMD), which is an adult onset disease characterized by eyelid drooping, difficulty in swallowing and weakness in the proximal limb muscles. Although significant data from...

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PMID: 20035013
DOI: 10.1093/hmg/ddp569

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Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesisPMID 20035013Read ↗

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