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Article

Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens.

Neuropharmacology - 1 Oct 2014

Singer Bryan F, Neugebauer Nichole M, Forneris Justin, Rodvelt Kelli R, Li Dongdong, Bubula Nancy, Vezina Paul

Abstract excerpt

Intermittent systemic exposure to psychostimulants leads to several forms of long-lasting behavioral plasticity including nonassociative sensitization and associative conditioning. In the nucleus accumbens (NAcc), the protein serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) and its phosphorylation target, the guanine-nucleotide exchange factor kalirin-7 (Kal7), may contribute to the neuroadaptations...

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Identifiers

PMID: 24939858
DOI: 10.1016/j.neuropharm.2014.05.033
PMCID: PMC4107072

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