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Antibody-induced glomerulonephritis is amplified by RTEC-intrinsic IL-17 signaling and restrained by IL-17-mediated induction of the endoribonuclease Regnase-1 ( <i>Zc3h12a</i> )

2021-01-11

Abstract excerpt

Antibody-mediated glomerulonephritis (AGN) is a clinical manifestation of many autoimmune kidney diseases for which few effective treatments exist. Chronic inflammatory circuits in renal glomerular and tubular cells lead to tissue damage in AGN. These cells are targeted by the cytokine IL-17, which has recently been shown to be a central driver of the pathogenesis of AGN. However, surprisingly little is known abou...

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Literature Corpus work
77f2e38f-bbc9-5e6e-a059-a47ad0792c80
DOI
10.1101/2021.01.11.425972
Open publication

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Antibody-induced glomerulonephritis is amplified by RTEC-intrinsic IL-17 signaling and restrained by IL-17-mediated induction of the endoribonuclease Regnase-1 ( <i>Zc3h12a</i> )DOI 10.1101/2021.01.11.425972
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