Article
The role of IL-23/IL-17 axis in lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2009
Zhang Zheng, Kyttaris Vasileios C, Tsokos George C
Abstract excerpt
T cells that express IL-17 infiltrate the kidneys of patients with systemic lupus erythematosus. A significant proportion of these cells are CD3(+)CD4(-)CD8(-) double-negative T cells. In this study, we show that double-negative T cells from MRL/lpr mice express high amounts of IL-17 and that as disease progressively worsens, the expression of IL-17 and of IL-23 receptor in lymphocytes from these mice increases....
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