Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB

8 Jan 2015

Abstract excerpt

BACKGROUND: The human myxovirus-resistance protein B (MxB, also called Mx2) was recently reported to inhibit HIV-1 infection by impeding the nuclear import and integration of viral DNA. However, it is currently unknown whether there exist MxB-resistant HIV-1 strains in the infected individuals. Answer to this question should address whether MxB exerts an inhibitory pressure on HIV-1 in vivo and whether HIV-1 has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to interferon and immune responses
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25571928
DOI: 10.1186/s12977-014-0129-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxBPMID 25571928Read ↗

Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations.Semantic proximity Read ↗

Host and Viral Determinants of Mx2 Antiretroviral ActivitySemantic proximity Read ↗

Naturally Occurring Mutations in HIV-1 CRF01_AE Capsid Affect Viral Sensitivity to Restriction Factors.Semantic proximity Read ↗

Evolutionary analysis identifies an MX2 haplotype associated with natural resistance to HIV-1 infection.Semantic proximity Read ↗

A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxBSemantic proximity Read ↗

Functional diversity of Mx proteins: variations on a theme of host resistance to infection.Semantic proximity Read ↗

Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus RestrictionSemantic proximity Read ↗

Naturally Occurring Capsid Substitutions Render HIV-1 Cyclophilin A Independent in Human Cells and TRIM-cyclophilin-resistant in Owl Monkey CellsSemantic proximity Read ↗

Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages.Semantic proximity Read ↗

Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis.Semantic proximity Read ↗

Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein.Semantic proximity Read ↗

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.