Article
Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models.
Carcinogenesis - 1 Oct 2009
Jonker Martijs J, Bruning Oskar, van Iterson Maarten, Schaap Mirjam M, van der Hoeven Tessa V, Vrieling Harry, Beems Rudolf B, de Vries Annemieke, van Steeg Harry, Breit Timo M, Luijten Mirjam
Abstract excerpt
The carcinogenic potential of chemicals and pharmaceuticals is traditionally tested in the chronic, 2 year rodent bioassay. This assay is not only time consuming, expensive and often with a limited sensitivity and specificity but it also causes major distress to the experimental animals. A major improvement in carcinogenicity testing, especially regarding reduction and refinement of animal experimentation, could...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.