Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis.

Toxicology and applied pharmacology - 1 Dec 2017

Ishii Yuji, Kuroda Ken, Matsushita Kohei, Yokoo Yuh, Takasu Shinji, Kijima Aki, Nohmi Takehiko, Ogawa Kumiko, Umemura Takashi

Abstract excerpt

Protein phosphatase 2A (PP2A) is a serine-threonine phosphatase that regulates cell signaling pathways. Its inactivation is correlated with tumor malignancy, possibly due to the effects on cell differentiation and malignant cell transformation. Therefore, it has been noted that PP2A could be a promising target for cancer therapy. In our previous study of the hepatocarcinogen estragole (ES), cell proliferation may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Adducts
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase Kinases

Share to Protein Phosphatase 2

Share to Rad51 Recombinase

Share to Rats, Inbred F344

Share to Rats, Transgenic

Share to src-Family Kinases

Source

Identifiers

PMID: 29054680
DOI: 10.1016/j.taap.2017.10.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis.PMID 29054680Read ↗

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.Semantic proximity Read ↗

TGF ‐β cascade regulation by PPP 1 and its interactors –impact on prostate cancer development and therapySemantic proximity Read ↗

Inhibition of PP2A activity confers a TRAIL-sensitive phenotype during malignant transformation.Semantic proximity Read ↗

Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action.Semantic proximity Read ↗

Carcinogen-Specific Gene Expression Profiles in Short-term Treated Eker and Wild-type Rats Indicative of Pathways Involved in Renal TumorigenesisSemantic proximity Read ↗

Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.Semantic proximity Read ↗

Carcinogenesis Associated with Toxin Nephropathy: Proposed Mediation by Phosphate ToxicitySemantic proximity Read ↗

Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient MiceSemantic proximity Read ↗

The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancersSemantic proximity Read ↗

Cell cycle regulation and p53 activation by protein phosphatase 2C alpha.Semantic proximity Read ↗

The hamster cheek pouch carcinogenesis modelSemantic proximity Read ↗

Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.