Article
Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats.
Cancer science - 1 May 2015
Akagi Jun-Ichi, Toyoda Takeshi, Cho Young-Man, Mizuta Yasuko, Nohmi Takehiko, Nishikawa Akiyoshi, Ogawa Kumiko
Abstract excerpt
Transgenic rodents carrying reporter genes to detect organ-specific in vivo genetic alterations are useful for risk assessment of genotoxicity that causes cancer. Thus, the Organization for Economic Co-operation and Development has established the guideline for genotoxicity tests using transgenic animals, which may be combined with repeated-dose toxicity studies. Here, we provide evidence to support equivalence...
Topics
- Animals
- Carcinogens
- Diethylhexyl Phthalate
- Diethylnitrosamine
- Dose-Response Relationship, Drug
- Liver
- Male
- Mutagenicity Tests
- Mutation
- Organ Size
- Rats, Inbred F344