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Article

Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats.

Cancer science - 1 May 2015

Akagi Jun-Ichi, Toyoda Takeshi, Cho Young-Man, Mizuta Yasuko, Nohmi Takehiko, Nishikawa Akiyoshi, Ogawa Kumiko

Abstract excerpt

Transgenic rodents carrying reporter genes to detect organ-specific in vivo genetic alterations are useful for risk assessment of genotoxicity that causes cancer. Thus, the Organization for Economic Co-operation and Development has established the guideline for genotoxicity tests using transgenic animals, which may be combined with repeated-dose toxicity studies. Here, we provide evidence to support equivalence...

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Identifiers

PMID: 25683344
DOI: 10.1111/cas.12634
PMCID: PMC4452153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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