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Article

Lack of genotoxic mechanisms in early-stage furan-induced hepatocellular tumorigenesis in gpt delta rats.

Journal of applied toxicology : JAT - 1 Feb 2017

Hibi Daisuke, Yokoo Yu, Suzuki Yuta, Ishii Yuji, Jin Meilan, Kijima Aki, Nohmi Takehiko, Nishikawa Akiyoshi, Umemura Takashi

Abstract excerpt

Furan has been used as an intermediate in the chemical-manufacturing industry and has been shown to contaminate various foods. Although furan induces hepatocellular tumors in rodents, equivocal results from in vitro and in vivo mutagenicity tests have caused controversy regarding the involvement of genotoxic mechanisms in furan-induced carcinogenesis. In the present study, to elucidate the possible mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27143483
DOI: 10.1002/jat.3331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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