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Article

The role of theSHHgene in prostate cancer cell resistance to paclitaxel

12 Jun 2014

Abstract excerpt

BACKGROUND: The increased activity of the Sonic Hedgehog (SHH) pathway has been demonstrated in many types of cancer including prostate cancer (PCa). It has been shown that SHH pathway is involved in tumor angiogenesis and in regulation of metabolism of cancer stem cells. The increased activity of the SHH pathway is responsible for generation and maintenance of the multidrug resistance in cancer cells. A key role...

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PMID: 24925370
DOI: 10.1002/pros.22830

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