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Article

Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency

14 Aug 2018

Abstract excerpt

One of the crucial challenges in the clinical management of cancer is resistance to chemotherapeutics. Multidrug resistance (MDR) has been intensively studied, and one of the most prominent mechanisms underlying MDR is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. Despite research efforts to develop compounds that inhibit the efflux activity of ABC transporters and thereby...

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PMID: 30110910
DOI: 10.3390/cells7080107

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