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Article

Smoothened as a new therapeutic target for human osteosarcoma

12 Jan 2010

Abstract excerpt

BACKGROUND: The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway in various types of malignancies. However, it remains unclear how Hedgehog pathway is involved in the pathogenesis of osteosarcoma. To explore the involvement of aberrant Hedgehog pathway in the pathogenesis of osteosarcoma, we investigated the...

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PMID: 20067614
DOI: 10.1186/1476-4598-9-5

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