Article
SHBG is an important factor in stemness induction of cells by DHT in vitro and associated with poor clinical features of prostate carcinomas.
PloS one - 1 Jan 2013
Ma Yuanyuan, Liang Dongming, Liu Jian, Wen Jian-Guo, Servoll Einar, Waaler Gudmund, Sæter Thorstein, Axcrona Karol, Vlatkovic Ljiljana, Axcrona Ulrika, Paus Elisabeth, Yang Yue, Zhang Zhiqian, Kvalheim Gunnar, Nesland Jahn M, Suo Zhenhe
Abstract excerpt
Androgen plays a vital role in prostate cancer development. However, it is not clear whether androgens influence stem-like properties of prostate cancer, a feature important for prostate cancer progression. In this study, we show that upon DHT treatment in vitro, prostate cancer cell lines LNCaP and PC-3 were revealed with higher clonogenic potential and higher expression levels of stemness related factors CD44,...
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