Article
Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.
Pancreas - 1 Mar 2012
Bahra Marcus, Kamphues Carsten, Boas-Knoop Sabine, Lippert Steffen, Esendik Ulrike, Schüller Ulrich, Hartmann Wolfgang, Waha Andreas, Neuhaus Peter, Heppner Frank, Pietsch Torsten, Koch Arend
Abstract excerpt
OBJECTIVES: Activation of the hedgehog signal transduction pathway, triggered by hedgehog binding to the transmembrane receptor patched 1 (PTCH1) or by mutations in the PTCH1 gene, plays an important role in the development of various tumors. METHODS: To investigate whether the Hedgehog signaling pathway is also active in human pancreatic adenocarcinomas, we determined the expression levels of the known Hedgehog...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.