Hedgehog pathway activity in the LADY prostate tumor model

Abstract excerpt

BACKGROUND: Robust Hedgehog (Hh) signaling has been implicated as a common feature of human prostate cancer and an important stimulus of tumor growth. The role of Hh signaling has been studied in several xenograft tumor models, however, the role of Hh in tumor development in a transgenic prostate cancer model has never been examined. RESULTS: We analyzed expression of Hh pathway components and conserved Hh target...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hedgehog Signaling Pathway Studies
• Share to Prostate Cancer Treatment and Research
• Share to TGF-β signaling in diseases