Article
The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo.
Oncotarget - 20 Dec 2016
Gonnissen Annelies, Isebaert Sofie, McKee Chad M, Dok Rüveyda, Haustermans Karin, Muschel Ruth J
Abstract excerpt
Limited data exists regarding the combination of Hedgehog signaling (Hh) inhibition and radiotherapy, even though there are several indications that this might be a promising treatment strategy. In this study, we evaluated the combination of two Hh inhibitors, the SMO inhibitor GDC-0449 and the GLI inhibitor GANT61 with radiotherapy in different prostate cancer (PCa) models. In vitro, GANT61 was able to sensitize...
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