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Article

GANT‐61 and GDC‐0449 induce apoptosis of prostate cancer stem cells through a GLI‐dependent mechanism

12 Dec 2017

Abstract excerpt

Aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway promotes prostate cancer (PC) growth and progression by regulating cancer-related genes through its downstream effectors GLI1 and GLI2. Therefore, targeting the SHH-GLI pathway provides an alternative approach to avoid cancer progression. The aim of this study was to delineate the underlying molecular mechanisms by which GDC-0449 (a SMO receptor...

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PMID: 29231999
DOI: 10.1002/jcb.26572

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