Back to search

Article

Dihydroartemisinin Sensitizes Esophageal Squamous Cell Carcinoma to Cisplatin by Inhibiting Sonic Hedgehog Signaling

2020-07-06

Abstract excerpt

<h4>Background: </h4> Platinum-based regimens have been routinely used in the clinical treatment of patients with esophageal squamous cell carcinoma (ESCC). However, administration of these drugs is frequently accompanied by drug resistance. Revealing the underlying mechanisms of the drug resistance and developing agents that enhance the sensitivity to platinum may provide new therapeutic strategies for the patien...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3d43aaad-b460-50d0-93be-f3c3887de04e
DOI
10.21203/rs.3.rs-39625/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Dihydroartemisinin Sensitizes Esophageal Squamous Cell Carcinoma to Cisplatin by Inhibiting Sonic Hedgehog SignalingDOI 10.21203/rs.3.rs-39625/v1
Dihydroartemisinin downregulates the expression of COX-2 in esophageal squamous cell carcinoma through ROS/MAPK/Sp1 axisSemantic proximity
The impact of<i>ERP29</i>on the progression of pharyngeal squamous cell carcinomaSemantic proximity
Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-cateninSemantic proximity
The Utility of Hedgehog Signaling Pathway Inhibition for CancerSemantic proximity
Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular MechanismsSemantic proximity
GLI1-mediated regulation of side population is responsible for drug resistance in gastric cancerSemantic proximity
Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathwaySemantic proximity
The role of theSHHgene in prostate cancer cell resistance to paclitaxelSemantic proximity
RNF149 confers cisplatin resistance in esophageal squamous cell carcinoma via destabilization of PHLPP2 and activating PI3K/AKT signallingSemantic proximity
Beyond cyclopamine: Targeting Hedgehog signaling for cancer interventionSemantic proximity
Hedgehog Inhibitors in Rhabdomyosarcoma: A Comparison of Four Compounds and Responsiveness of Four Cell LinesSemantic proximity
Valproic Acid Synergizes With Cisplatin and Cetuximab in vitro and in vivo in Head and Neck Cancer by Targeting the Mechanisms of ResistanceSemantic proximity
Select a neighboring publication to make it the new centre.