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Article

Prediction and biological significance of small changes in binding of leiomodin to tropomyosin.

The Journal of general physiology - 7 Jul 2025

Sánchez Díaz Eduardo, Osegueda Brayan, Minakhina Svetlana, Starks Nickolas, Novak Stefanie, Tolkatchev Dmitri, Gregorio Carol C, Kostyukova Alla S, Smith Garry E

Abstract excerpt

In cardiac muscle, regulation of actin polymerization at the thin filament pointed end is controlled by two structurally similar but functionally antagonistic proteins, leiomodin-2 and tropomodulin-1. Both proteins contain tropomyosin-binding site 1, which is essential for their recruitment to the pointed end. Using circular dichroism, we determined changes in melting temperatures (ΔTm) for complexes of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40272387
DOI: 10.1085/jgp.202413641
PMCID: PMC12020486

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Prediction and biological significance of small changes in binding of leiomodin to tropomyosin.PMID 40272387Read ↗

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