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Article

Tropomodulin isoforms utilize specific binding functions to modulate dendrite development.

Cytoskeleton (Hoboken, N.J.) - 1 Jun 2016

Gray Kevin T, Suchowerska Alexandra K, Bland Tyler, Colpan Mert, Wayman Gary, Fath Thomas, Kostyukova Alla S

Abstract excerpt

Tropomodulins (Tmods) cap F-actin pointed ends and have altered expression in the brain in neurological diseases. The function of Tmods in neurons has been poorly studied and their role in neurological diseases is entirely unknown. In this article, we show that Tmod1 and Tmod2, but not Tmod3, are positive regulators of dendritic complexity and dendritic spine morphology. Tmod1 increases dendritic branching distal...

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Identifiers

PMID: 27126680
DOI: 10.1002/cm.21304
PMCID: PMC4916160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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