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Impact of cytochrome P450 3A5 polymorphism in graft livers on the frequency of acute cellular rejection in living-donor liver transplantation.

Pharmacogenetics and genomics - 1 Jul 2014

Uesugi Miwa, Kikuchi Mio, Shinke Haruka, Omura Tomohiro, Yonezawa Atsushi, Matsubara Kazuo, Fujimoto Yasuhiro, Okamoto Shinya, Kaido Toshimi, Uemoto Shinji, Masuda Satohiro

Abstract excerpt

OBJECTIVE: We investigated whether the cytochrome P450 3A5*3 (CYP3A5*3) genotype affects tacrolimus pharmacokinetics and the risk of acute cellular rejection in living-donor liver transplant patients in Japan. MATERIALS AND METHODS: Between July 2004 and June 2011, we enrolled 410 living-donor liver transplant patients receiving tacrolimus. Biopsy specimens of intestinal mucosa and graft liver at surgery were...

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PMID: 24911663
DOI: 10.1097/FPC.0000000000000060

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ABO

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