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Article

Polymorphism of the CYP3A5 gene and its effect on tacrolimus blood level.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Apr 2015

Nair Sreeja S, Sarasamma Sreeja, Gracious Noble, George Jacob, Anish Thekkumkara Surendran Nair, Radhakrishnan Reghunathan

Abstract excerpt

OBJECTIVES: Tacrolimus is the cornerstone for immunosuppression in renal transplant and is metabolized by the cytochrome P 450 3A (CYP3A) subfamily of enzymes in the liver and small intestine. A polymorphism in intron 3 of the CYP3A5 gene affects the expression of this enzyme and tacrolimus trough blood levels. The purpose of this study was to identify the proportion of CYP3A5 gene polymorphisms in South Indian...

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PMID: 25894154

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