Article
Association of CYP3A4*18B and CYP3A5*3 polymorphism with cyclosporine-related liver injury in Chinese renal transplant recipients.
International journal of clinical pharmacology and therapeutics - 1 Jun 2014
Xin Hua-wen, Liu Hui-ming, Li Yuan-qi, Huang Hui, Zhang Li, Yu Ai-rong, Wu Xiao-chun
Abstract excerpt
OBJECTIVE: The purpose of this study was to investigate the associations between CYP3A4*18B and CYP3A5*3 polymorphism and cyclosporine-related liver injuries in Chinese renal transplant recipients. METHODS: We genotyped 339 renal transplant recipients treated with a triple immunosuppressive regimen including cyclosporine for CYP3A4*18B and CYP3A5*3 polymorphism using the polymerase chain reaction restriction...
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