Article
Influence of cytochrome P450 (CYP) 3A4*1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients.
Biological & pharmaceutical bulletin - 1 Jan 2013
Uesugi Miwa, Hosokawa Mio, Shinke Haruka, Hashimoto Emina, Takahashi Tamotsu, Kawai Tomoki, Matsubara Kazuo, Ogawa Kohei, Fujimoto Yasuhiro, Okamoto Shinya, Kaido Toshimi, Uemoto Shinji, Masuda Satohiro
Abstract excerpt
Association between cytochrome P450 (CYP) 3A4*1G genotype of donors (n=412) and/or recipients (n=410), and the pharmacokinetics of tacrolimus and the risk of acute cellular rejection was examined in Japanese living-donor liver transplant patients between 2004 and 2011. The concentration/dose (C/D) ratio of tacrolimus in patients carrying graft liver with CYP3A4*1/*1 was significantly higher during 7 d after...
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