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Article

Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients.

Pharmacogenetics and genomics - 1 May 2008

Fukudo Masahide, Yano Ikuko, Yoshimura Atsushi, Masuda Satohiro, Uesugi Miwa, Hosohata Keiko, Katsura Toshiya, Ogura Yasuhiro, Oike Fumitaka, Takada Yasutsugu, Uemoto Shinji, Inui Ken-ichi

Abstract excerpt

OBJECTIVE: The potential influence of the multidrug resistance 1 (MDR1) gene and the cytochrome P450 (CYP) genes, CYP3A4 and CYP3A5, on the oral clearance (CL/F) of tacrolimus in adult living-donor liver transplant patients was examined. Furthermore, the development of renal dysfunction was analy...

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Identifiers

PMID: 18408564
DOI: 10.1097/FPC.0b013e3282f9ac01

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18408564-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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