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Article

CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation.

Pharmacogenetics - 1 Jul 2004

Goto Maki, Masuda Satohiro, Kiuchi Tetsuya, Ogura Yasuhiro, Oike Fumitaka, Okuda Masahiro, Tanaka Koichi, Inui Ken-ichi

Abstract excerpt

OBJECTIVES: Tacrolimus is widely used for immunosuppressive therapy after organ transplantation, but its pharmacokinetics shows such great interindividual variation that control of its blood concentration is difficult. We have previously reported that an intestinal P-glycoprotein (MDR1) contributes to this variation as an absorptive barrier, but the role of hepatic metabolism is not clear. METHODS: In this study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15226679
DOI: 10.1097/01.fpc.0000114747.08559.49

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation.PMID 15226679Read ↗

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