Article
Long-Term Influence of CYP3A5 Gene Polymorphism on Pharmacokinetics of Tacrolimus and Patient Outcome After Living Donor Liver Transplantation.
Transplantation proceedings - 1 May 2016
Kato H, Usui M, Muraki Y, Tanemura A, Murata Y, Kuriyama N, Azumi Y, Kishiwada M, Mizuno S, Sakurai H, Okuda M, Nakatani K, Isaji S
Abstract excerpt
BACKGROUND: We investigated a long-term association between donor/recipient CYP3A5 polymorphisms, pharmacokinetics of tacrolimus, and recipient outcomes in settings of living donor liver transplantation (LDLT). METHODS: From February 2002 to November 2009, 67 couples of donor/recipients with tacrolimus administration, who could be genotyped for CYP3A5*3 and *1, were eligible in this study. We compared the...
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