Article
Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients.
Annals of transplantation - 1 Jan 2000
Muraki Yuichi, Usui Masanobu, Isaji Shuji, Mizuno Shugo, Nakatani Kaname, Yamada Tomomi, Iwamoto Takuya, Uemoto Shinji, Nobori Tsutomu, Okuda Masahiro
Abstract excerpt
BACKGROUND: The impact of cytochrome P450 3A5 (CYP3A5) genotype of recipients (intestine) as well as donors (graft liver) on the tacrolimus pharmacokinetics and the incidence of infectious complications was assessed in Japanese living-donor liver transplant (LDLT) adult recipients. MATERIAL/METHODS: Fifty-six patients were divided into 4 groups based on the CYP3A5 genotype (expression of *1 allele: expressor (EX)...
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