Article
Effects of combinational CYP3A5 6986A>G polymorphism in graft liver and native intestine on the pharmacokinetics of tacrolimus in liver transplant patients: a meta-analysis.
Therapeutic drug monitoring - 1 Aug 2014
Buendia Jefferson A, Bramuglia Guillermo, Staatz Christine E
Abstract excerpt
BACKGROUND: Many studies have reported reduced tacrolimus dose-adjusted exposure in individuals expressing the CYP3A5*1 allele. A meta-analyses of the current data may help characterize the extent of impact this polymorphism has on tacrolimus pharmacokinetics in adult liver transplant recipients and whether donor or recipient genotype is the most influential factor. METHODS: Structured searches, of studies that...
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