Article
Combinational effect of intestinal and hepatic CYP3A5 genotypes on tacrolimus pharmacokinetics in recipients of living donor liver transplantation.
Transplantation - 27 Oct 2012
Ji Eunhee, Choi Leena, Suh Kyung-Suk, Cho Joo-Youn, Han Nayoung, Oh Jung Mi
Abstract excerpt
BACKGROUND: For living donor liver transplantation, the genetic association of CYP3A5 genotype of recipient's native intestine and donor's liver allograft with tacrolimus pharmacokinetics has not been explained completely considering liver regeneration time. The goal of the study was to investigate the longitudinal effects of recipient-donor combinational CYP3A5 genotypes on tacrolimus dose-normalized...
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