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The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates α-synuclein aggregation and membrane binding.

Biochemistry - 21 Oct 2014

Ghosh Dhiman, Sahay Shruti, Ranjan Priyatosh, Salot Shimul, Mohite Ganesh M, Singh Pradeep K, Dwivedi Saumya, Carvalho Edmund, Banerjee Rinti, Kumar Ashutosh, Maji Samir K

Abstract excerpt

α-Synuclein (α-Syn) oligomerization and amyloid formation are associated with Parkinson's disease (PD) pathogenesis. Studying familial α-Syn mutants associated with early onset PD has therapeutic importance. Here we report the aggregation kinetics and other biophysical properties of a newly discovered PD associated Finnish mutation (A53E). Our in vitro study demonstrated that A53E attenuated α-Syn aggregation and...

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PMID: 25268550
DOI: 10.1021/bi5010365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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