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Article

N-terminal KTKEGV motif lysine residues of α-Synuclein are critical for TLR2 interaction and activation.

Archives of biochemistry and biophysics - 1 Feb 2026

Bisht Krishna Singh, Kumari Manisha, Maiti Tushar Kanti

Abstract excerpt

Synucleinopathies, such as Parkinson's Disease, involve widespread intracellular protein aggregates. α-synuclein (αSyn) protein contributes majorly to these aggregates called as Lewy Bodies, which are linked to neurodegeneration. αSyn has been shown to transmit from infected to healthy neurons, thus spreading the pathology. During its transmission, αSyn is also known to activate microglia by interacting with the...

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PMID: 41386390
DOI: 10.1016/j.abb.2025.110701

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TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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