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Article

Role of Integrin Alpha4 in Drug Resistance of Leukemia

23 May 2014

Abstract excerpt

Chemotherapeutic drug resistance in acute lymphoblastic leukemia (ALL) is a significant problem, resulting in poor responsiveness to first-line treatment or relapse after transient remission. Classical anti-leukemic drugs are non-specific cell cycle poisons; some more modern drugs target oncogenic pathways in leukemia cells, although in ALL these do not play a very significant role. By contrast, the molecular...

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PMID: 24904821
DOI: 10.3389/fonc.2014.00099

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