Article
Integrin alphavbeta3 enhances β-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity.
Oncotarget - 28 Jun 2016
Yi Hai, Zeng Dongfeng, Shen Zhaohua, Liao Jun, Wang Xiaoguo, Liu Yao, Zhang Xi, Kong Peiyan
Abstract excerpt
Binding of leukemia cells to the bone marrow extracellular matrix (ECM) through integrins might influence drug response and the survival of acute myeloid leukemia (AML). However, the functions of integrin in AML are needed to be clarified. Data from The Cancer Genome Atlas (TCGA) were retrieved and integrin β3 (ITGB3) expression and prognostic significance for AML were analyzed. Integrin alphavbeta3 (αvβ3) in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.