Article
Growth factor signaling and resistance to cancer chemotherapy.
Current topics in medicinal chemistry - 1 Jan 2004
Dai Zunyan, Huang Ying, Sadée Wolfgang
Abstract excerpt
Multiple mechanisms contribute to chemoresistance, eventually leading to failure of cancer chemotherapy. Deregulated growth factor signaling pathways promote cell proliferation and render cancer cells resistant to apoptosis, a common mechanism of chemoresistance. Therefore, inhibitors of growth factor signaling, including antibodies and small molecules, are promising drug candidates for chemotherapy, either given...
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