Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrins in Cancer Drug Resistance: Molecular Mechanisms and Clinical Implications

28 Mar 2025

Abstract excerpt

It is estimated that between 80 and 90% of mortality in cancer patients is directly or indirectly related to drug resistance. Consequently, overcoming drug resistance represents a significant challenge in the treatment of cancer. Integrins are transmembrane adhesion molecules that facilitate the linkage between the extracellular matrix (ECM) and the cytoskeleton, thereby enabling the activation of various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cell Adhesion Molecules Research
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40243917
DOI: 10.3390/ijms26073143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrins in Cancer Drug Resistance: Molecular Mechanisms and Clinical ImplicationsPMID 40243917Read ↗

Integrins and cancer.Semantic proximity Read ↗

Beyond adhesion: emerging roles for integrins in control of the tumor microenvironmentSemantic proximity Read ↗

Integrins and extracellular matrix: a novel mechanism of multidrug resistanceSemantic proximity Read ↗

Integrins regulate stemness in solid tumor: an emerging therapeutic target.Semantic proximity Read ↗

Integrins: a role as cell signalling molecules.Semantic proximity Read ↗

Integrins Within the Tumor Microenvironment: Biological Functions and Advances in Therapeutic Targeting <strong> </strong>Semantic proximity Read ↗

Integrins: roles in cancer development and as treatment targetsSemantic proximity Read ↗

Integrin signaling in tumor biology: mechanisms of intercellular crosstalk and emerging targeted therapiesSemantic proximity Read ↗

The complexity of integrins in cancer and new scopes for therapeutic targetingSemantic proximity Read ↗

Role of Integrins in Cancer: Survey of Expression PatternsSemantic proximity Read ↗

Integrin-Mediated Tumorigenesis and Its Therapeutic ApplicationsSemantic proximity Read ↗

Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell MigrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.