Article

β2 Integrin Antagonism, A Potential Mechanism To Sensitize CML Cells To Therapy As Revealed From Genetic Response To Radiation And LiCl

2021-09-29

Abstract excerpt

<h4>Background: </h4> The interaction of integrins and growth factor receptors in cells is tightly regulated, ensuring cell survival, proliferation, differentiation, adhesion, and migration. The IR generates reactive oxygen species, which leads to ECM remodeling and cell adhesion through the activation of proteases, soluble cytokines and growth factors. Integrins and adhesion of cells to ECM confer higher resistan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75a4b9c3-7589-54da-ab88-ba96cdcb2f73
DOI: 10.21203/rs.3.rs-885452/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

β2 Integrin Antagonism, A Potential Mechanism To Sensitize CML Cells To Therapy As Revealed From Genetic Response To Radiation And LiClDOI 10.21203/rs.3.rs-885452/v1Read

Portrait of inflammatory response to ionizing radiation treatmentSemantic proximity Read

Expression Profiling of Glioblastoma Cell Lines Reveals Novel Extracellular Matrix-Receptor Genes Correlated With the Responsiveness of Glioma Patients to Ionizing RadiationSemantic proximity Read

Cadherins, Selectins, and Integrins in CAM-DR in LeukemiaSemantic proximity Read

Phenotypic and functional characterization of subpopulation of Imatinib resistant chronic myeloid leukemia cell line.Semantic proximity Read

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow MicroenvironmentSemantic proximity Read

Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and ChemotherapySemantic proximity Read

Role of Integrin Alpha4 in Drug Resistance of LeukemiaSemantic proximity Read

Integrins in Cancer Drug Resistance: Molecular Mechanisms and Clinical ImplicationsSemantic proximity Read

Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cellsSemantic proximity Read

CD24−/low stem-like breast cancer marker defines the radiation-resistant cells involved in memorization and transmission of radiation-induced genomic instabilitySemantic proximity Read

Hypoxic Conditions Confer Chemoresistance to Crizotinib but Not to Imatinib in Chronic Myeloid Leukemia (CML) Cells Depending on HIF1α and JAK2Semantic proximity Read

Hypoxic Conditions Confer Chemoresistance to Crizotinib but not to Imatinib in Chronic Myeloid Leukemia (CML) Cells Depending on HIF1α and JAK2Semantic proximity Read