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Article

Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib

5 Jun 2020

Abstract excerpt

The interaction of multiple myeloma (MM) cells with the bone marrow (BM) microenvironment promotes MM cell retention, survival, and resistance to different anti-MM agents, including proteasome inhibitors (PIs) such as bortezomib (BTZ). The α4β1 integrin is a main adhesion receptor mediating MM cell-stroma interactions and MM cell survival, and its expression and function are downregulated by BTZ, leading to...

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PMID: 32501543
DOI: 10.1002/path.5480

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