Article
Apolipoprotein L1 and mechanisms of kidney disease susceptibility.
Current opinion in nephrology and hypertension - 1 May 2021
Bruggeman Leslie A, Sedor John R, O'Toole John F
Abstract excerpt
PURPOSE OF REVIEW: Allelic variants in the gene for apolipoprotein L1 (APOL1), found only in individuals of African ancestry, explain a majority of the excess risk of kidney disease in African Americans. However, a clear understanding how the disease-associated APOL1 variants cause kidney injury and the identity of environmental stressors that trigger the injury process have not been determined. RECENT FINDINGS:...
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