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Article

Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats.

Nucleic acids research - 5 May 2017

Nguyen Jennifer H G, Viterbo David, Anand Ranjith P, Verra Lauren, Sloan Laura, Richard Guy-Franck, Freudenreich Catherine H

Abstract excerpt

Trinucleotide repeats are a source of genome instability, causing replication fork stalling, chromosome fragility, and impaired repair. Specialized helicases play an important role in unwinding DNA structures to maintain genome stability. The Srs2 helicase unwinds DNA hairpins, facilitates replication, and prevents repeat instability and fragility. However, since Srs2 is a multifunctional protein with helicase...

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Share to Chromosome Fragility
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exodeoxyribonucleases

Share to Genome, Fungal

Share to Inverted Repeat Sequences

Share to Proliferating Cell Nuclear Antigen

Share to Rad51 Recombinase

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Source

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Identifiers

PMID: 28175398
DOI: 10.1093/nar/gkx088
PMCID: PMC5416882

Genes

PCNA

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Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats.PMID 28175398Read ↗

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