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Article

Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin.

Cancer research - 15 Oct 2018

Hiller Björn, Hoppe Anja, Haase Christa, Hiller Christina, Schubert Nadja, Müller Werner, Reijns Martin A M, Jackson Andrew P, Kunkel Thomas A, Wenzel Jörg, Behrendt Rayk, Roers Axel

Abstract excerpt

Because of imperfect discrimination against ribonucleoside triphosphates by the replicative DNA polymerases, large numbers of ribonucleotides are incorporated into the eukaryotic nuclear genome during S-phase. Ribonucleotides, by far the most common DNA lesion in replicating cells, destabilize the DNA, and an evolutionarily conserved DNA repair machinery, ribonucleotide excision repair (RER), ensures...

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Identifiers

PMID: 30154151
DOI: 10.1158/0008-5472.CAN-18-1099
PMCID: PMC6526525

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