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Article

Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.

Molecular and cellular biology - 1 Sept 2004

Bhattacharyya Saumitri, Lahue Robert S

Abstract excerpt

Trinucleotide repeats (TNRs) undergo frequent mutations in families afflicted with certain neurodegenerative disorders and in model organisms. TNR instability is modulated both by the repeat tract itself and by cellular proteins. Here we identified the Saccharomyces cerevisiae DNA helicase Srs2 a...

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Share to DNA Helicases
Share to DNA Polymerase III
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Recombination, Genetic

Share to Saccharomyces cerevisiae Proteins

Share to Trinucleotide Repeat Expansion

Share to Trinucleotide Repeats

Source

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Identifiers

PMID: 15314145
DOI: 10.1128/MCB.24.17.7324-7330.2004
PMCID: PMC507003

Genes

TNR
RAD51
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15314145-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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