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Article

IDH1(R132H) mutation increases U87 glioma cell sensitivity to radiation therapy in hypoxia.

BioMed research international - 1 Jan 2014

Wang Xiao-Wei, Labussière Marianne, Valable Samuel, Pérès Elodie A, Guillamo Jean-Sébastien, Bernaudin Myriam, Sanson Marc

Abstract excerpt

OBJECTIVE: IDH1 codon 132 mutation (mostly Arg132His) is frequently found in gliomas and is associated with longer survival. However, it is still unclear whether IDH1 mutation renders the cell more vulnerable to current treatment, radio- and chemotherapy. MATERIALS AND METHODS: We transduced U87 with wild type IDH1 or IDH1 (R132H) expressing lentivirus and analyzed the radiosensitivity (dose ranging 0 to 10 Gy)...

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Share to Cell Hypoxia
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Radiation Tolerance

Share to Real-Time Polymerase Chain Reaction

Share to Transduction, Genetic

Share to Tumor Stem Cell Assay

Source

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Identifiers

PMID: 24895549
DOI: 10.1155/2014/198697
PMCID: PMC4033346

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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