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Article

Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2015

Shi Jinlong, Sun Baolan, Shi Wei, Zuo Hao, Cui Daming, Ni Lanchun, Chen Jian

Abstract excerpt

Gliomas are the most malignant and aggressive primary brain tumor in adults. Despite concerted efforts to improve therapies, their prognosis remains very poor. Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered frequently in glioma patients and are strongly correlated with improved survival. However, the effect of IDH1 mutations on the chemosensitivity of gliomas remains unclear. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25283382
DOI: 10.1007/s13277-014-2644-z

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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