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Article

IDH1(R132H) mutation causes a less aggressive phenotype and radiosensitizes human malignant glioma cells independent of the oxygenation status.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Sept 2015

Kessler Jacqueline, Güttler Antje, Wichmann Henri, Rot Swetlana, Kappler Matthias, Bache Matthias, Vordermark Dirk

Abstract excerpt

BACKGROUND AND PURPOSE: In malignant glioma the presence of the IDH1 mutation (IDH1(R132H)) is associated with better clinical outcome. However, it is unclear whether IDH1 mutation is associated with a less aggressive phenotype or directly linked to increased sensitivity to radiotherapy. MATERIAL...

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Source

Identifiers

PMID: 26328938
DOI: 10.1016/j.radonc.2015.08.007

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26328938-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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IDH1(R132H) mutation causes a less aggressive phenotype and radiosensitizes human malignant glioma cells independent of the oxygenation status.PMID 26328938Read ↗

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